Dysbindin Modulates Prefrontal Cortical Glutamatergic Circuits and Working Memory Function in Mice
نویسندگان
چکیده
منابع مشابه
[Hippocampal-prefrontal cortical circuit and working memory].
The study on learning and memory is one of the striking subjects in neuroscience today. In the cerebral cortex, it is has been proved that, the hippocampus, the prefrontal cortex and the hippocampal-prefrontal cortical circuit are important to working memory. In this paper, we review findings of the anatomical and electrophysiological characteristics of the hippocampal-prefrontal cortical circu...
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Studies of human amnesia provide evidence for a short-term memory store with information transfer to long term memory occurring within 60 s of sensory encoding. Human and nonhuman primate research has shown that maintenance of this short-term or working memory store is dependent upon frontal cortical activation, although the critical temporal parameters of frontal involvement throughout this 60...
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Working memory (WM) declines with advancing age. Brain imaging studies indicate that ventral prefrontal cortex (PFC) is active when information is retained in WM and that dorsal PFC is further activated for retention of large amounts of information. The authors examined the effect of aging on activation in specific PFC regions during WM performance. Six younger and 6 older adults performed a ta...
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BACKGROUND Dysfunction in prefrontal cortex (PFC) GABA transmission has been proposed to contribute to cognitive dysfunction in schizophrenia, yet how this system regulates different cognitive and mnemonic functions remains unclear. METHODS We assessed the effects of pharmacological reduction of GABAA signaling in the medial PFC of rats on spatial reference/working memory using different vers...
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The present study investigated brain mechanisms underlying auditory memory. In a modified Sternberg memory scanning task, 11 subjects indicated whether a probe sound was part of a previously presented 4-item memory set by a button press. Behaviorally, subjects responded fastest and most accurately to probes that matched the last memory set items and slowest and least accurately to negative prob...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2009
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2009.90